Gene-Set Analysis via Decorrelation by Orthogonal Transformation R package dotgen version 0.1.1 Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>. Software Depends: R (>= 3.5.0), mvtnorm Xiaoran Tong <xt@uky.edu> Comprehensive R Archive Network (CRAN) Olga Vsevolozhskaya [aut] (ORCID: <https://orcid.org/0000-0001-9376-3645>), Dmitri Zaykin [aut] (ORCID: <https://orcid.org/0000-0002-9444-2859>), Xiaoran Tong [aut, cre] (ORCID: <https://orcid.org/0000-0002-4648-3330>) GPL (>= 2) 2024-10-27 application/tgz https://CRAN.R-project.org/package=dotgen doi:10.32614/CRAN.package.dotgen