Hierarchical Optimal Matching and Machine Learning Toolbox R package hamlet version 0.9.8 Various functions and algorithms are provided here for solving optimal matching tasks in the context of preclinical cancer studies. Further, various helper and plotting functions are provided for unsupervised and supervised machine learning as well as longitudinal mixed-effects modeling of tumor growth response patterns. Software Depends: R (>= 3.0.0) Imports: grDevices, graphics, stats, utils Suggests: lme4, nlme, amap, nbpMatching, lattice, lmerTest, xtable, Cairo, Matrix, MASS Teemu Daniel Laajala <teelaa@utu.fi> Comprehensive R Archive Network (CRAN) Teemu Daniel Laajala [aut, cre] GPL (>= 2) 2025-12-09 application/tgz https://CRAN.R-project.org/package=hamlet doi:10.32614/CRAN.package.hamlet