Simultaneous Critical Values for t-Tests in Very High Dimensions R package highTtest version 1.4 Implements the method developed by Cao and Kosorok (2011) for the significance analysis of thousands of features in high-dimensional biological studies. It is an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the k-familywise error rate, false discovery rate, and the tail probability of false discovery proportion. Software Depends: methods, grid, VennDiagram Shannon T. Holloway <shannon.t.holloway@gmail.com> Comprehensive R Archive Network (CRAN) Hongyuan Cao [aut], Michael Kosorok [aut], Shannon T. Holloway [aut, cre] GPL-2 2025-05-04 application/tgz https://CRAN.R-project.org/package=highTtest doi:10.32614/CRAN.package.highTtest