POINT: Protein Structure Guided Local Test

Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

Version: 1.3
Depends: methods, stats, rARPACK, Matrix, CompQuadForm
Published: 2023-10-01
DOI: 10.32614/CRAN.package.POINT
Author: Rachel Marceau West, Shannon T. Holloway
Maintainer: Shannon T. Holloway <shannon.t.holloway at gmail.com>
License: GPL-2
NeedsCompilation: no
Materials: NEWS
CRAN checks: POINT results


Reference manual: POINT.pdf


Package source: POINT_1.3.tar.gz
Windows binaries: r-devel: POINT_1.3.zip, r-release: POINT_1.3.zip, r-oldrel: POINT_1.3.zip
macOS binaries: r-release (arm64): POINT_1.3.tgz, r-oldrel (arm64): POINT_1.3.tgz, r-release (x86_64): POINT_1.3.tgz, r-oldrel (x86_64): POINT_1.3.tgz
Old sources: POINT archive


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