CRAN Task View: Clinical Trial Design, Monitoring, and Analysis

Maintainer:Ed Zhang, W. G. Zhang, R. G. Zhang
Contact:ClinicalTrials.TaskView at
Contributions:Suggestions and improvements for this task view are very welcome and can be made through issues or pull requests on GitHub or via e-mail to the maintainer address. For further details see the Contributing guide.
Citation:Ed Zhang, W. G. Zhang, R. G. Zhang (2021). CRAN Task View: Clinical Trial Design, Monitoring, and Analysis. Version 2021-12-29. URL
Installation:The packages from this task view can be installed automatically using the ctv package. For example, ctv::install.views("ClinicalTrials", coreOnly = TRUE) installs all the core packages or ctv::update.views("ClinicalTrials") installs all packages that are not yet installed and up-to-date. See the CRAN Task View Initiative for more details.

This task view gathers information on specific R packages for design, monitoring and analysis of data from clinical trials. It focuses on including packages for clinical trial design and monitoring in general plus data analysis packages for a specific type of design. Also, it gives a brief introduction to important packages for analyzing clinical trial data. Please refer to task views ExperimentalDesign, Survival, Pharmacokinetics, Meta-analysis for more details on these topics.

Contributions are always welcome and encouraged, either via e-mail to the maintainer or by submitting an issue or pull request in the GitHub repository linked above.

Design and Monitoring

Design and Analysis

Analysis for Specific Designs

Analysis in General


CRAN packages

Core:adaptTest, asd, bcrm, blockrand, clinfun, dfcrm, experiment, Hmisc, ldbounds, longpower, PowerTOST, pwr, speff2trial, survival, TEQR, TrialSize.
Regular:accrualPlot, adaptr, clinicalsignificance, clinsig, coin,, cosa, CRM, crmPack, ctrdata, dfped, DoseFinding, DTAT, epibasix, ewoc, FrF2, HH, MCPMod, Mediana, meta, metafor, metaLik, metasens, MinEDfind, mmrm, multcomp, nppbib, PowerUpR, presize, randomizeR, rbmi, replicateBE, rmeta, rpact, samplesize, simglm, ssanv, ThreeGroups, UnifiedDoseFinding.
Archived:AGSDest, binomSamSize, clusterPower, dfpk, ThreeArmedTrials.

Related links

Other resources