nlmixr2extra: Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

Version: 2.0.10
Depends: R (≥ 4.0)
Imports: checkmate, cli (≥ 3.4.0), crayon, data.table, digest, ggplot2, ggtext, knitr, lotri, methods, nlme, nlmixr2est (≥ 2.1.1), Rcpp, rxode2 (≥ 2.0.10), stats, symengine, utils
LinkingTo: Rcpp, RcppArmadillo
Suggests: brms, nlmixr2data, testthat (≥ 3.0.0), withr, dplyr, devtools, rxode2parse
Published: 2024-05-29
DOI: 10.32614/CRAN.package.nlmixr2extra
Author: Matthew Fidler ORCID iD [aut, cre], Vipul Mann [aut], Vishal Sarsani ORCID iD [aut], Christian Bartels [ctb], Bill Denney ORCID iD [aut]
Maintainer: Matthew Fidler <matthew.fidler at>
License: GPL (≥ 3)
NeedsCompilation: yes
Citation: nlmixr2extra citation info
Materials: README NEWS
CRAN checks: nlmixr2extra results


Reference manual: nlmixr2extra.pdf


Package source: nlmixr2extra_2.0.10.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): nlmixr2extra_2.0.10.tgz, r-oldrel (arm64): nlmixr2extra_2.0.10.tgz, r-release (x86_64): nlmixr2extra_2.0.10.tgz, r-oldrel (x86_64): nlmixr2extra_2.0.10.tgz
Old sources: nlmixr2extra archive

Reverse dependencies:

Reverse imports: nlmixr2, nlmixr2plot, nlmixr2rpt


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