nlmixr2: Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 2.1.2
Depends: nlmixr2data
Imports: nlmixr2est (≥ 2.2.2), nlmixr2extra (≥ 2.0.10), rxode2 (≥ 2.1.3), lotri (≥ 0.4.3), nlmixr2plot (≥ 2.0.8), magrittr, crayon, cli
Suggests: rmarkdown, knitr, devtools, ggplot2, testthat, n1qn1, rxode2parse (≥ 2.0.19), withr
Published: 2024-05-30
DOI: 10.32614/CRAN.package.nlmixr2
Author: Matthew Fidler ORCID iD [aut, cre], Yuan Xiong [ctb], Rik Schoemaker ORCID iD [ctb], Justin Wilkins ORCID iD [ctb], Wenping Wang [ctb], Mirjam Trame [ctb], Huijuan Xu [ctb], John Harrold [ctb], Bill Denney ORCID iD [ctb], Theodoros Papathanasiou [ctb], Teun Post [ctb], Richard Hooijmaijers [ctb]
Maintainer: Matthew Fidler <matthew.fidler at>
License: GPL (≥ 3)
NeedsCompilation: no
Citation: nlmixr2 citation info
Materials: README NEWS
In views: DifferentialEquations, HighPerformanceComputing, MixedModels, Pharmacokinetics
CRAN checks: nlmixr2 results


Reference manual: nlmixr2.pdf


Package source: nlmixr2_2.1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): nlmixr2_2.1.2.tgz, r-oldrel (arm64): nlmixr2_2.1.2.tgz, r-release (x86_64): nlmixr2_2.1.2.tgz, r-oldrel (x86_64): nlmixr2_2.1.2.tgz
Old sources: nlmixr2 archive

Reverse dependencies:

Reverse depends: babelmixr2
Reverse imports: nlmixr2rpt
Reverse suggests: ggPMX, tidyvpc, xpose.nlmixr2


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